ارتباط سطح سرمی آدیپسین با سندرم تخمدان پلی کیستیک (PCOS)

  Background : Adipokines are proteins secreted from adipose tissue that are involved in metabolism control. Adipsin is one of the adipokines that has a systemic role in lipid metabolism or physiological systems relating to energy balance. Serum levels are found to be associated with BMI, and insulin resistance in several studies. The aim of this study was to assess adipsins association with Poly Cystic Ovary Syndrome (PCOS).   Methods: This case-control study was performed on patients who referred to the clinic of the Research Institute for Endocrine Sciences of Shahid-Beheshti University in 2011. Forty five patients with PCOS and 45 normal individuals as control group were selected by easy given sampling method and studied. Fasting adipsin and insulin serum levels were measured by Elisa method and fasting glucose serum level was measured by enzyme-calorimetric method. Data were analyzed using independent t-test, Pearson correlation coefficient and one-way ANOVA by SPSS 16 software.   Results: Adipsin serum levels did not correlate with insulin resistance in PCOS (15.93±7.24 ng/dl in PCOS patients and 14.21±7.53 ng/dl in control group). Glucose and insulin serum levels increased in PCOS (104.1±13.4 mg/dl and 10.8±5.2 mU/L respectively) in comparison with controls and these PCOS patients had insulin resistance.   Conclusion: This study does not show the correlation between adipsin level and PCOS. It is possible to find a relationship between PCOS and adipsin through expanding the population or limiting the age levels.